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UID:20@crc-network-catalysis.de
DTSTART;TZID=Europe/Berlin:20250206T140000
DTEND;TZID=Europe/Berlin:20250206T150000
DTSTAMP:20250122T122836Z
URL:https://www.crc-network-catalysis.de/events/catalysis-joint-colloquium
 -prof-amir-hoveyda/
SUMMARY:CataLysis - Joint Colloquium: Prof. Amir Hoveyda
DESCRIPTION:We are very happy to welcome within the Joint Online Colloquium
  Series of the CataLysis network hosted by CRC 1333:\nProf. Amir H. Hoveyd
 a\nBoston College\, USA/ University of Strasbourg\, France\nCatalytic Clic
 k Processes that Forge Functional Linkages\nWe cordially invite all member
 s of the CataLysis network to the lecture.\nThe link to the video conferen
 ce will be circulated within the CataLysis Network via E-Mail.\nAbstract:\
 nClick reactions that generate functional linkages are desirable but scarc
 e\, and among the less than a handful of catalytic options\, none delivers
  a clippable connector. In this Lecture the development of copper(I)-catal
 yzed allene-ketone addition (CuAKA) will be presented. CuAKA\, despite bei
 ng promoted by Cu(I) complex\, is mutually orthogonal to CuAAC (copper(I)-
 catalyzed azide–alkyne cycloaddition) and the more recently introduced C
 uPDF (copper(I)-catalyzed phenoxydiazaborinine formation). These click pro
 cesses can be merged for rapid and diversifiable assembly of multifunction
 al entities. CuAKA-generated linkages can be ruptured in dilute aqueous H2
 O2\, a reactive oxygen species (ROS)\, the higher concentration of which i
 n a cell foreshadows diseases such as cancer and diabetes. CuAKA has been 
 used for efficient linking of anti-cancer agent camptothecin to unprotecte
 d penetratin\, a cell-penetrating peptide\, with payload release occurring
  in a 68 μM aqueous solution of H2O2 at 37 °C.
CATEGORIES:CataLysis Joint Online Colloquium
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